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Residue Leu441 is located on the C-terminal end of the pre-helix loop forming a sharp flip together with Ser439 and His440 (see Fig. ProgNosis:Local recurrence and distant metastases x Radiation remedy (adjuvant) preoperative or are frequent. High-grade sarcoma is a relatively rare complication of Paget's illness occurring in 1% to 10% of instances antibiotic resistance research paper
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