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Breast cancer is a heterogeneous disease, but 70% of cases are characterized by the presence of hormone receptors for estrogen, progesterone, or both. The first line of treatment for these patients, when presenting with metastatic disease, is endocrine therapy nike high dunk in combination with CDK4/6 inhibitors, but the majority develops resistance to treatment within two years. Now, a new study led bySandra Casimiro, staff scientist at theInstituto de Medicina Molecular Jo茫o Lobo Antunes (iMM; Portugal),and Lu铆s Costa, principal investigator at theiMM and oncologist at the H adidas yeezys ospital Santa Maria (Portugal),and published today in the scientific journalCell Reports Medicine*,found a promising molecular target in cancer cells that could be used in combination with the standard care converse chucks to avoid resistance to treatment in metastatic breast cancer.鈥淐urrently, the first-line of care treatment for metastatic luminal breast cancer, which expresses receptors for estrogen and/or progesterone, is the combination of ISLAMABAD:Prime Minister Nawaz Sharif on Tuesday said China's National Energy Administration (NEA) could expand and diversify its investment in the power sector of Pakistan by joining the process of setting up transmission lines and coal-fired power projects.In a meeting with NEA Chairman Nur Bekri, Premier Nawaz said both the countries were working for the prosperity of the people of the region through joint economic and develo adidas campus 00's pment efforts.Acknowledging the support of NEA, the prime minister said that completion o stanley brand f energy projects on fast track basis would help Paki newbalance 574 stan in overcoming energy crisis.The PM said Pakistan was fully committed to the timely and effective implementation of all projects under the China-Pakistan Economic Corridor (CPEC).Sahiwal project launch: Some elements oppose China ties: Shehbaz"Pakistan shares Chinese vision of regional and global economic integration through strengthening connectivity which is the reason why Pakistan is among the early partners in the