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Revumenib is being developed by the company Syndax. Its meant to work by inhibiting a protein called menin, which seems to play an important role in certain forms of leukemia. These cancers are characterized by carrying a NPM1 gene mutation or a
stanley cups rearrangement of another gene, called KMT2A. These aberrations are commonly found in both pediatric and adult cases of
stanley cups leukemia and are often very hard to treat. According to research cited by the scientists, for instance, the five-year survival rate for KMT2A-related leukemia is less than 25%. On Thursday, these researchers published results from the first human trial of revumenib in the journal Nature. The trial enrolled 68 patients with relapsed or refractory acute leukemia that had failed to respond to previous treatments. Most of these patients had NPM1/KMT2A-related cancer. Phase I trials are designed to test the safety and optimal dose of an experimental treatment. But to understand its potential efficacy, the team also looked at the outcomes of those with NPM1/KMT2A-related leukemia 60 in total . Out of these eligible patients, 53% showed some response to revumenib, and about 30% 18 patients showed complete remission. Though nearly all of the patients experienced adverse effects, including potentially serious ones like an irregular heartbeat, none had to stop treatment as a result.
stanley cupe For patients with acute leukemia who have undergone several previous treatments, this is a very encouraging result, said study author Scot Stvy Two U.S. Children Died From a Brain-Eating Amoeba This Month
Neither is true鈥攎ainstream uses for quantum computers are at least a few years to a decade away, and the big fear, that quantum algorithms will crack popular encryption strategies, is probably several decades away. Still, experts say weve entered a new era of quantum computing, and c
stanley cup ompanies have begun putting out commercial products. IBM just recently announced a device catered to a commercial audience, and other companies like Google, Rigetti, and IonQ now or will soon offer access to cloud-based quantum processors. Meanwhile, NASA, Lockheed Martin, and Los Alamos National Lab have already purchased thousand-qubit quantum simulators for approximately $10 million to $15 million from a smaller, newer company we sometimes overlook, called D-Wave. You might wonder why people would buy such an expensive device when the technology in such an early stage. Its mostly still research and experimental, Bo Ewald, D-Wave Internationals president, told Gizmodo. No production applications yet. So why use bother with one of these devices We posed that question to researche
stanley cup rs using D-Wave computers at Lockheed Martin, Los Alamos National Lab, Volkswagen, and elsewhere. In short, D
stanley usa -Waves are in their early days, but these organizations are hoping to eventually use them to solve problems, like predicting elections, routing taxis in traffic jams, or picking crucial data out of background noise. They want to start approaching these puzzles from a quantum computing mindset as early as p
