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Cells communicate through
dunk low complex mechanisms that typically involve receptors and ligands that bind to them. Endogenous ligands, produced by the body, have been identified for the vast majority of cellular receptors, helping explain receptor existence and func
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dunks nike low ion. But in the case of sigma-1 receptors, which interact with a diverse array of psychoactive drugs, an endogenous ligand has remained elusive.A new study shows that choline, an essential nutrient that functions in metabolism, is an endogenous activator of sigma-1 receptors, marking an important advance in cell biology.鈥淪igma-1 receptors are targets of psychoactive drugs that are commonly abused,鈥?explained Eugen Brailoiu, MD, Adjunct Associate Professor at the Center for Substance Abuse Research (CSAR) at LKSOM, and lead author on the new report. 鈥淣ow we show that choline not only is the physiological activator of these receptors but also functions as a second messenger, relaying intracellular signals from sigma-1 receptors to Chinese state media on Wednesday criticised the United States for hindering efforts to stop global cyber threats in the wake of the WannaCry "ransomware" attack that has infected more than 300,000 computers worldw
adidas campus grise ide in recent days.The US National Security Agency (NSA) should shoulder some blame for the attack, which targets vulnerabilities in Microsoft Corp systems and has infected some 30,000 Chinese organisations as of Saturday, the China Daily said.Manhunt for hack
adidas samba beige ers behind global cyberattack"Concerted efforts to tackle cyber crimes have been hindered by the actions of the United States," it said, adding that Washington had "no credible evidence" to support bans on Chinese tech firms in the US following the attack.The malware attack, which began on Friday and
new balance blanche has been linked by some researchers to previous hits by a North Korean-run hacking operation, leveraged a tool built by the NSA that leaked online in April, Microsoft says.It comes as China prepares to enforce a wide-reaching
