In a steroid analogue synthesis programme aiming to develop novel antiovulation contraceptive hormonal drugs, clomiphene was identified in a series of non-steroidal triphenylethylene compounds including chlorotrianisene and ethamoxytriphetol MER-25 and, later, tamoxifen.
tamoxifen action In addition, the increase in breast fat with weight gain may lead to pseudogynecomastia, which may or may not be associated with true gynecomastia 17-26.
