Could there be various options or could new strategies potentially be developed. The penetrance of the C282Y mutation, which is essentially the most frequent mutation causing hereditary haemochromatosis, has recently been estimated to be within the region of 1% (Beutler et al, 2002) to 25% (European Haemochromatosis Consortium, 2002). Cl and K+ are transported into the lumen, which is necessary for secretion of acid
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