Placental mosaicism can also be associated with uniparental disomy (inheritance of two homologous chromosomes from one father or mother), which often leads to development restriction. Adjuvant radiotherapy for stage I endometrial most cancers: an up to date Cochrane systematic evaluate and meta-evaluation. Substance dependence is a situation that falls inside the substance misuse defnition and, for the purposes of this normal, is characterised by a number of of the following features: • tolerance, as defned by both a necessity for markedly increased quantities of the substance to achieve intoxication or desired impact, or a markedly diminished impact with continued use of the same amount of substance; • withdrawal, as manifested by both the characteristic withdrawal syndrome for the substance, or the identical (or a intently related) substance is taken to alleviate or avoid withdrawal symptoms; • the substance is usually taken in larger quantities or during an extended time period than was intended; • there is a persistent want or unsuccessful efforts to chop down or control substance use; • a substantial amount of time is spent in actions to obtain the substance, use the substance or recover from its effects; • important social, occupational or leisure activities are given up or lowered because of substance use; and the substance use is sustained regardless of knowledge of having a persistent or recurrent bodily or psychological downside that's likely to have been caused or exacerbated by the substance
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