Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 usually are not mutated in individuals with attenuated adenomatous polyposis coli. Careful surveillance and the judicious use of salvage remedy on the time of brain relapse enable appropriate patients to benefit from the highest high quality of life with no detriment in total survival. Histologically, it is characterised by undifferentiated neuroblast aggregates which might be separated by fibrovascular septae
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